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and diabetes
 43,n° 2, 2014,pages 186-195, 86 réf
prevost (gaëtan), eas (florence), kuhn (jean-marc)
diabète et maladies métaboliques
la fréquence du diabète et/ou du syndrome métabolique s’accroît parallèlement à l’élévation de l’index de masse corporelle (imc)
chez l’homme adulte, le taux de testostérone plasmatique évolue inversement au chiffre de l’imc
les taux de testostérone plasmatique totale, de protéine porteuse des stéroïdes sexuels (shbg) et de testostérone libre sont significativement inférieurs chez les hommes adultes dont le profil clinico-biologique correspond au syndrome métabolique (smet) par rapport à ceux qui en sont dépourvus
après. ajustement pour des facteurs confondants, le diabète de type 2 (dt2) reste associé à une réduction significative de la testostéronémie
le blocage androgénique utilisé comme thérapie du carcinome prostatique disséminé est inducteur d’un profil métabolique de type smet
chez l’homme de plus de 65 ans, un abaissement du taux de testostérone plasmatique est significativement associé à un risque accru d’accident vasculaire cérébral ou de décès de cause cardiovasculaire
en l’absence de contre-indications, la compensation d’un déficit confirmé en testostérone chez le patient obèse. ayant a fortiori un profil de smet ou un dt2, pourrait apporter des bénéfices métaboliques et cardiovasculaires
mots-clés bdsp : plasma sanguin, obésité, diabète, glande endocrine [pathologie]
mots-clés pascal : testostérone, plasma sanguin, obésité, syndrome métabolique, diabète, etat nutritionnel, androgène, hormone stéroïde sexuelle, hormone testiculaire, trouble de la nutrition, pathologie de l’appareil circulatoire, endocrinopathie, maladie métabolique
mots-clés pascal anglais : testosterone, blood plasma, obesity, metabolic syndrome, diabetes mellitus, nutritional status, androgen, sex steroid hormone, testicular hormone, nutrition disorder, cardiovascular disease, endocrinopathy, metabolic diseases
notice produite par :
inist-cnrs – institut de l’information scientifique et technique
transférer dans zotero comment se procurer ce document ?
comment interroger la base ?
format de la base de données
nous avons le regret de vous informer de la fermeture du portail bdsp le 1er juillet 2019
du 1er janvier au 30 juin 2019, le site et ses services resteront accessibles mais ne seront plus alimentés, ni mis à jour
banque de données en santé publique – http://www
fermeture du portail bdsp le 1er juillet 2019
l e taux de testostérone baisse. d’environ 1 % par an chez les hommes à partir de 40 ans, et c’est tout à fait naturel
cette baisse est parfois accompagnée de certains symptômes : baisse de libido, problèmes érectiles, fatigue, dépression, ostéoporose, que l’on regroupe sous le vocable « andropause », et qui n’affectent qu’un homme sur cinq
ces mêmes symptômes peuvent également être tout simplement liés au vieillissement
pourquoi, alors, le marché des produits de testostérone (les stéroïdes anabolisant s, par exemple) est-il en pleine effervescence ? surtout pour des raisons esthétiques
on estime que le marché des suppléments de testostérone a déjà atteint 2 milliards de dollars , seulement aux États-unis
on prévoitqu’il atteindra 5 milliards en 2017
au canada, les prescriptions de ces médicaments auraient augmenté de 4000 % entre 2000 et 2011
c’est sans compter les achats qui se font en ligne, sur le marché noir — en théorie, ces produits ne se vendent que sur ordonnance d’un médecin
ces produits stimulent la croissance des muscles et le développement des caractères sexuels masculins
dans beaucoup de cas, les hommes en prennent pour avoir l’air plus « mâles », sans nécessairement ressentir les symptômes de l’andropause
c’est un médicament ! 
les médecins sont très prudents lorsqu’ils prescrivent un traitement de remplacement de la testostérone (et ne le font jamais pour ses propriétés anabolisantes),

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a large nose and a mustache, which avoided the need to draw a mouth and facial expressions
miyamoto envisioned a “go to” character that could be put into any game as needed, albeit in cameo appearances, as at the time miyamoto was not expecting the character to become singularly popular
[8] to this end, he originally called the character “mr
video”, comparing his intent for appearances in later games to the cameos that alfred hitchcock had done within his films
[16] over time, mario’s appearance has become more defined; blue eyes, white gloves, brown shoes, a red “m” in a white circle on the front of his hat and gold buttons on his overalls have been added
the colors of his shirt and overalls were also reversed from a blue shirt with red overalls to a red shirt with blue overalls
miyamoto attributed this process to the different development teams and artists for each game as well as advances in technology
nintendo did not initially reveal mario’s full name
in a 1989 interview, his full name was stated not to be “mario mario” though it may be inferred from the title of the mario bros
[17] the first notable use of “mario mario” is in the 1993 live-action film adaptation
this was again used in two of prima’s official strategy guides, in 2000[18] for mario party 2 and in 2003[19] for mario and luigi: superstar saga
in 2012 after charles martinet voiced mario declaring himself “mario mario” at the san diego comic-con[20] the next month satoru iwata said he had no last name,[21] which shigeru miyamoto agreed with the month after
[22] two months after iwata’s death in july 2015, miyamoto changed his stance september 2015 at the super mario bros
30th anniversary festival, asserting that his name was indeed mario mario
mario debuted as “jumpman” in the arcade game donkey kong on july 9, 1981
[25] he is shown to be a carpenter and has a pet ape called donkey kong
[26] the carpenter mistreats the ape and donkey kong escapes to kidnap jumpman’s girlfriend, originally known as the lady, but later named pauline
the player must take the role of jumpman and rescue the girl
jumpman was later renamed “mario” in the 1982 arcade game donkey kong junior, the only game in which he has been portrayed as an antagonist
in the 1983 arcade game mario bros
, mario and his younger brother luigi are portrayed as italian-american[11] plumbers[27] who have to defeat creatures that have been coming from the sewers below new york city
for the nintendo entertainment system, mario saves princess toadstool (later known as princess peach) of the mushroom kingdom from king koopa
[28] to save princess toadstool, mario conquers the eight worlds of the mushroom kingdom by going to the castle in each to defeat a minion of king koopa
to reach each castle, mario battles through three sub-worlds by defeating king koopa’s henchmen
if mario successfully fights his way through the castle and defeats the minion, he frees a mushroom retainer
[citation needed ] inside the eighth castle, mario has a final fight with king koopa and frees princess toadstool
2, the player can choose between mario, luigi, toad, or princess peach
each character possesses unique abilities (luigi has stronger jumping ability, toad can dig the fastest, and peach can float), with mario being the most well-rounded
3, mario quests to save the rulers of seven kingdoms from bowser and his children, the koopalings, and mario travels across eight worlds to restore order to the mushroom world and to rescue princess peach
[29] mario is introduced to new power-ups that augment his abilities
in super mario land, an alien named tatanga appears, hypnotizes the inhabitants of an area called sarasaland, and kidnaps its ruler, princess daisy
mario sets out to rescue her, traveling through the four geographical areas of sarasaland and defeating tatanga’s minions along the way
he corners tatanga in the skies of the chai kingdom, bringing down the alien warship and rescuing daisy
[31] in super mario world, mario and luigi take princess peach for a vacation in dinosaur world sometime after the events of super mario bros
3; during the vacation, peach is kidnapped by bowser
mario and luigi meet the yoshis, dinosaurs that live in dinosaur world, and they help rescue peach by allowing mario and luigi to ride them
[32] in super mario land 2: 6 golden coins, whose events take place immediately after the original super mario land, mario’s evil counterpart wario has put an evil spell over mario land while mario was away in sarasaland, renaming the area wario land
the inhabitants are brainwashed into thinking that wario is their master and mario is their enemy
wario’s motive behind this sudden attack was to take control over mario’s castle in order to have one of his own
to stop wario, mario finds the 6 golden coins throughout mario land and regains access to his castle
in super mario world 2: yoshi’s island, a stork carries baby mario and baby luigi across the sea, but the evil magikoopa kamek steals baby luigi, and baby mario falls onto an island called yoshi’s island, home to yoshis
after mario meets the yoshis, the group journeys through the game’s six worlds to rescue baby luigi and the stork from baby bowser and kamek
mario made his 3d debut in super mario 64 for the nintendo 64
[33] princess peach sends mario a letter inviting him to join her at her castle for cake;[34] however, when he arrives, mario discovers that bowser has invaded the castle and imprisoned the princess and her servants within it using the castle’s 120 power stars
many of the castle’s paintings are portals to other worlds, in which bowser’s minions guard the stars
mario explores the castle and other worlds to recover the stars
he gains access to more painting portals as he recovers more stars,[35] and he traverses three obstacle courses that lead him to battles with bowser
defeating bowser the first two times earns mario keys that open new levels of the castle,[36] while the final battle releases peach, who rewards mario by baking the cake that she promised him
in super mario sunshine, mario, toadsworth, and princess peach take a vacation to isle delfino, a tropical island
a person resembling mario, known as “shadow mario”, vandalizes and pollutes the entire island using a magic paintbrush
the vandalism has caused the shine sprites to flee from the island’s main city, delfino plaza, and blanket the island in darkness
blamed for the mess, mario is arrested by the island authorities and ordered to clean up isle delfino
mario is equipped with fludd, a robotic hosing device invented by professor e
gadd, which he uses to clean up the pollution and collect the shine sprites
[38] meanwhile, peach is kidnapped by shadow mario, who reveals himself to be bowser jr
, one of bowser’s children, having stolen the paintbrush from professor e
mario eventually confronts bowser and bowser jr
with the island cleaned up, mario and peach begin their vacation
5d in new super mario bros
while mario and peach take a walk together through the mushroom kingdom, bowser jr
[40] mario gives chase, venturing through eight worlds
mario eventually catches up, defeating both bowser and bowser jr
[41] in super mario galaxy, mario is invited by princess peach to the centennial star festival in the mushroom kingdom
[42] upon arrival, bowser invades the kingdom and rips peach’s castle from its foundations and lifts it into outer space
after failing to prevent the princess from being kidnapped, mario meets star-like creatures called lumas and their companion, rosalina
rosalina tells mario that bowser has stolen the power stars, the source of power for rosalina’s mobile observatory, and has taken peach to the center of the universe
mario then travels to various galaxies to reclaim the power stars to restore power to the observatory and reclaim princess peach
[43] in new super mario bros
5d game, mario, luigi, and two toads are attending princess peach’s birthday party when bowser jr
and the other seven koopalings ambush the princess and kidnap her
mario, luigi, and the two toads chase after them across eight worlds, defeating each koopaling as they progress
the quartet eventually confronts bowser, defeating him and saving the princess
[44] in super mario galaxy 2, bowser, who has transformed himself into a giant using the power stars, attacks the mushroom kingdom and abducts peach, taking her to the center of the universe
with the help of the lumas, mario pilots starship mario, a mobile planet in the shape of his head, in order to travel to various galaxies and gather the power stars, used to fuel the ship
after multiple battles against both bowser and bowser jr
, mario eventually arrives at bowser’s lair at the center of the universe, where he defeats him and rescues the princess
[45] in 2012, mario returned in new super mario bros
2 where he collects several coins scattered across the mushroom kingdom in addition to saving princess peach from the evil clutches of bowser and the koopalings
mario returns to defeat bowser and his minions in new super mario bros
mario is one of the playable characters in super mario 3d world, where he has average running speed and jump height compared to other characters
mario is the protagonist of the nintendo switch game super mario odyssey, where the character cappy replaces mario’s traditional hat, allowing mario to throw it like a long-range weapon, and “capture” enemies to gain their abilities
mario games of other genres include various game & watch games; mario pinball land, a pinball game for the game boy advance;[46] various educational games; and the dr
mario puzzle video game, (with dr
mario itself first released in 1990)
mario throws vitamins that the player must align to destroy the viruses that populate the playing field
[47] 1996’s super mario rpg is the first mario role-playing game;[48] ten games have followed, including five in the paper mario series (paper mario for the nintendo 64, paper mario: the thousand-year door for the gamecube, super paper mario for the wii, paper mario: sticker star for the nintendo 3ds, and paper mario: color splash for the wii u) and six in the mario & luigi series (mario & luigi: superstar saga for the game boy advance, mario & luigi: partners in time and mario & luigi: bowser’s inside story for the nintendo ds, mario & luigi: dream team, mario & luigi: paper jam, and mario & luigi: superstar saga + bowser’s minions for the nintendo 3ds)
several other sub-series of mario video games, especially those inspired from sports, have been released
the mario kart franchise, which began with super mario kart for the super nintendo entertainment system in 1992, is the most successful and longest-running kart racing franchise
[49] other mario sports games include the camelot-developed series mario golf and mario tennis, and, respectively, the baseball and soccer games mario superstar baseball and super mario strikers
in 1999, hudson soft developed the mario party series, which began on the nintendo 64
the games revolve around a set of minigames and are playable with up to four players
mario & sonic at the olympic games, released for both nintendo ds and wii, is

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